A look at the devastation caused in the aftermath of Hurricane Sandy from North Carolina to New England.
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Video gamers in the Northeast angling to be among the first to play the highly anticipated "Assassin's Creed III" will have to wait a little longer — even if they have power.
Area GameStop stores cancelled their midnight launches of Ubisoft's historical action sequel as Superstorm Sandy continued to disrupt the New York entertainment scene, including Broadway, talk shows, concerts and the premiere of "Anna Karenina."
New York City officials said that all film permits for Monday and Tuesday were revoked because of the storm and associated safety precautions.
"There will be no city authorized outdoor filming within the five boroughs," read a statement Monday from the Mayor's Office of Film, Theatre and Broadcasting.
Production was affected on several TV shows, including "Gossip Girl," ''Person of Interest," ''Smash," ''666 Park Avenue" and "Elementary." ''The Daily Show" and "The Colbert Report" also took Monday night off, and all 40 Broadway theaters will be dark through Tuesday.
The storm halted production on a few films as well, including Akiva Goldsman's "Winter's Tale" and Darren Aronofsky's "Noah."
"I take it that the irony of a massive storm holding up the production of 'Noah' is not lost," tweeted actress Emma Watson.
The storm forced Focus Features to postpone the Manhattan premiere of "Anna Karenina," which was set for Tuesday.
Jimmy Kimmel canceled his late night ABC talk show Monday. He was scheduled to host his Hollywood-based "Jimmy Kimmel Live!" all week from Brooklyn, where he was born. ABC said the network was hopeful Kimmel's show would return Tuesday with guests Howard Stern, Tracy Morgan, and Sharon Jones and the Dap Kings. David Letterman and Jimmy Fallon taped their talk shows without audiences.
"Theater owners here in New York had to cancel all the Broadway shows today," Fallon said in his opening monologue Monday. "Many performers were having trouble making it in to the city, and you could tell by that one show, 'Blue Man Guy.'"
Some network schedules were shaken up by the widespread power outages cutting into the available TV audience in the East.
CBS aired repeats instead of new episodes Monday night of "How I Met Your Mother," ''Partners," ''2 Broke Girls" and "Mike & Molly." A CBS News special on Sandy pre-empted "Hawaii Five-O."
The CW opted to air repeats of "90210" and "Gossip Girl."
ABC stuck to its schedule of new episodes of "Dancing with the Stars" and "Castle." Fox broadcast a previously scheduled rerun of "The X Factor," which had been planned if the San Francisco-Detroit World Series ended, as it did, in four games.
NBC aired fresh installments of "The Voice" and "Revolution."
Several stations interrupted network broadcasts with live news coverage of the storm.
ABC's "Good Morning America," NBC's "Today" show and "CBS This Morning" were expected to air live as usual Tuesday with extensive storm coverage. The daytime talk show "Live! With Kelly and Michael" planned to air a rerun Tuesday.
Sandy took a toll on the movie box office even before it made landfall. Ticket sales were down more than 11 percent compared to the same weekend last year, said Paul Dergarabedian, box-office analyst for Hollywood.com. This weekend's top film, "Argo," collected $12.1 million. The top film during the same weekend in 2011, "Puss in Boots," earned $34 million.
Several movie theaters remained closed Money night.
Concerts planned for New York and New Jersey were canceled or postponed, including performances by Journey, comedian Louis C.K., and the "Freedom to Love Now" show featuring Rufus Wainwright and fun., which is now set for spring of 2013.
Radio City Music Hall was shuttered until Wednesday. Carnegie Hall postponed concerts planned for Tuesday. Off-Broadway shows and even national tours of Broadway shows like "Anything Goes," currently in Wilmington, Del., closed their doors.
It was the most detrimental storm for the theater community since the threat of Hurricane Irene in late August 2011 prompted producers to cancel matinee and evening performances on both a Saturday and Sunday.
East Coast charity galas were also canceled, and fashion designer Prabal Gurung postponed the unveiling of his anticipated collection for Target until next week.
___
AP Entertainment Writers Mark Kennedy and Jake Coyle in New York, and Sandy Cohen and Lynn Elber in Los Angeles contributed to this report.
___
Follow AP Entertainment Writer Derrik J. Lang on Twitter at http://www.twitter.com/derrikjlang.
The theoretical work that would lead to the production of monoclonal antibodies started in the early 1970s, but The New York Times would not mention the term until May 1, 1979, in a roundup of science news. “A new San Diego firm,” an article on Page C2 said, “plans to manufacture and sell antibodies produced artificially by tissue-culture techniques.”
Antibodies circulate in the body until latching on to foreign cells, called antigens, which they destroy. Monoclonal antibodies are manufactured in the laboratory and then cloned, producing custom-designed and uniform antibodies that can attach to specific disease cells — bacteria, viruses or cancer cells — without injuring healthy tissue.
By the late 1970s, several new biotechnology companies, including Genentech and Hybritech, had already concluded that drugs made with monoclonal antibodies might be used to treat cancer and other diseases. On Jan. 27, 1980, in a front-page article headed “Advances in Gene Splicing Hint Scientific-Industrial Revolution,” Harold M. Schmeck Jr., took note of the dizzying speed at which the field was progressing. But he may have been somewhat too optimistic in predicting that “these feats of biological alchemy may be only spectacular curtain raisers for a new scientific-industrial revolution.”
On Aug. 18, 1984, Stuart Diamond would report in an article on Page 31 that “a biotechnology research company says it has produced the first commercial levels of human monoclonal antibodies for the treatment of disease.”
The Times announced the winners of the Nobel Prize in Physiology or Medicine on Page 1 on Oct. 16, 1984. The headline read “3 Immunology Investigators Win the Nobel Prize in Medicine,” and on the same day the paper published two other articles on the winners, along with an editorial by Nicholas Wade titled “Triumph of an ‘Unworkable’ Idea.”
Dr. Niels K. Jerne, who laid the theoretical groundwork, and Dr. George J. F. Köhler and Dr. César Milstein, who produced the first monoclonal antibodies, shared the prize. Yet it would be more than a decade before the first monoclonal antibody drug for use in humans would come to market.
On May 1, 1997, The Times reported that Genentech had filed for Food and Drug Administration approval of Rituximab, for the treatment of a specific form of non-Hodgkin’s lymphoma, a cancer of the lymph system. In clinical trials, the drug appeared to shrink tumors in about half the patients who took it. Rituximab is used today to treat not only non-Hodgkin’s lymphoma, but also chronic lymphocytic leukemia, rheumatoid arthritis and other diseases.
While none has proved to be a “magic bullet” for curing any disease, there are now dozens of monoclonal antibody drugs approved for diagnosis or treatment of various diseases, and hundreds more in development.
SEATTLE — Eric Horvitz joined Microsoft Research 20 years ago with a medical degree, a Ph.D. in computer science and no plans to stay. “I thought I’d be here six months,” he said.
He remained at M.S.R., as Microsoft’s advanced research arm is known, for the fast computers and the chance to work with a growing team of big brains interested in cutting-edge research. His goal was to build predictive software that could get continually smarter.
In a few months, Mr. Horvitz, 54, may get his long-awaited payoff: the advanced computing technologies he has spent decades working on are being incorporated into numerous Microsoft products.
Next year’s version of the Excel spreadsheet program, part of the Office suite of software, will be able to comb very large amounts of data. For example, it could scan 12 million Twitter posts and create charts to show which Oscar nominee was getting the most buzz.
A new version of Outlook, the e-mail program, is being tested that employs Mr. Horvitz’s machine-learning specialty to review users’ e-mail habits. It could be able to suggest whether a user wants to read each message that comes in.
Elsewhere, Microsoft’s machine-learning software will crawl internal corporate computer systems much the way the company’s Bing search engine crawls the Internet looking for Web sites and the links among them. The idea is to predict which software applications are most likely to fail when seemingly unrelated programs are tweaked.
If its new products work as advertised, Microsoft will find itself in a position it has not occupied for the last few years: relevant to where technology is going.
While researchers at M.S.R. helped develop Bing to compete with Google, the unit was widely viewed as a pretty playground where Bill Gates had indulged his flights of fancy. Now, it is beginning to put Microsoft close to the center of a number of new businesses, like algorithm stores and speech recognition services. “We have more data in many ways than Google,” said Qi Lu, who oversees search, online advertising and the MSN portal at Microsoft.
M.S.R. owes its increased prominence as much to the transformation of the computing industry as to its own hard work. The explosion of data from sensors, connected devices and powerful cloud computing centers has created the Big Data industry. Computers are needed to find patterns in the mountains of data produced each day.
“Everything in the world is generating data,” said David Smith, a senior analyst with Gartner, a technology research firm. “Microsoft has so many points of presence, with Windows, Internet Explorer, Skype, Bing and other things, that they could do a lot. Analyzing vast amounts of data could be a big business for them.”
Microsoft is hardly alone among old-line tech companies in injecting Big Data into its products. Later this year, Hewlett-Packard will showcase printers that connect to the Internet and store documents, which can later be searched for new information. I.B.M. has hired more than 400 mathematicians and statisticians to augment its software and consulting. Oracle and SAP, two of the largest suppliers of software to businesses, have their own machine-learning efforts.
In the long term, Microsoft hopes to combine even more machine learning with its cloud computing system, called Azure, to rent out data sets and algorithms so businesses can build their own prediction engines. The hope is that Microsoft may eventually sell services created by software, in addition to the software itself.
“Azure is a real threat to Amazon Web Services, Google and other cloud companies because of its installed base,” said Anthony Goldbloom, the founder of Kaggle, a predictive analytics company. “They have data from places like Bing and Xbox, and in Excel they have the world’s most widely used analysis software.”
Like other giants, Microsoft also has something that start-ups like Kaggle do not: immense amounts of money — $67 billion in cash and short-term investments at the end of the last quarter — and the ability to work for 10 years, or even 20, on a big project.
It has been a long trip for Microsoft researchers. M.S.R. employs 850 Ph.D.’s in 13 labs around the world. They work in more than 55 areas of computing, including algorithm theory, cryptography and computational biology.
Machine learning involves computers deriving meaning and making predictions from things like language, intentions and behavior. When search engines like Google or Bing offer “did you mean?” alternatives to a misspelled query, they are employing machine learning. Mr. Horvitz, now a distinguished scientist at M.S.R., uses machine learning to analyze 25,000 variables and predict hospital patients’ readmission risk. He has also used it to deduce the likelihood of traffic jams on a holiday when rain is expected.
Mr. Horvitz started making prototypes of the Outlook assistant about 15 years ago. He keeps digital records of every e-mail, appointment and phone call so the software can learn when his meetings might run long, or which message he should answer first.
“Major shifts depend on incremental changes,” he said.
At a retreat in March, 100 top Microsoft executives were told to think of new ways that machine learning could be used in their businesses.
“It’s exciting when the sales and marketing divisions start pulling harder than we can deliver,” Mr. Horvitz said. “Magic in the first go-round becomes expectation in the next.”
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